Our collaborative study with Prof. Tae-Eun Park on brain delivery systems for treatment of Alzheimer’s disease has been published in ACS Nano. In this study, we have utilized the microphysiological systems (MPS) mimicking human blood-brain barrier on a chip to discover BBB-penetrating aptamers. The MPS-derived aptamers showed remarkable BBB penetration efficiency, led by clathrin-mediated transcytosis. By adopting the BBB-penetrating aptamer, we also showed noticeable efficacy of brain delivery of nanoparticles as well.
Check out our recent study at ACS Nano: https://pubs.acs.org/doi/10.1021/acsnano.2c11675