A new perspective paper focusing on micro- and nanorobotics-based drug delivery systems designed to penetrate the blood-brain barrier (BBB) has been published in Matter. The article is titled “Bridging the barrier: Micro- and nanorobotics for active brain delivery,” and Dr. Jounghyun Yoo from our laboratory led the work as the first author. This paper reviews […]

Our latest research on enhancing immunotherapy efficacy by modulating the tumor immune microenvironment using biodegradable nanoparticles has been published in Acta Biomaterialia. The paper is titled “Degradation-Controlled Synchronization of HIF-2α and MEK Inhibition Using Self-Sealed Porous Silicon Nanoparticles to Reprogram Tumor Immunogenicity.” Juyoung led this study as the first author. This work represents a key […]

Our research on CRISPR RNP delivery technology using lipid-silica hybrid nanoparticles has been published in the journal Small. The paper is titled “FAST-CRISPR: Fusogenic Association and Secured Transfection of CRISPR/Cas9 Ribonucleoproteins Using Lipid-Silica Hybrid Nanoparticles for Therapeutic Genome Editing”. Minjong led this study as the first author. This work introduces a direct cytosolic delivery system […]

Our paper on a novel technology for the precise diagnosis and prognosis of hepatocellular carcinoma (HCC) via metabolite profile analysis has been published in Biomarker Research. The study is titled “Liver-specific propanoate metabolism-derived 2-ethylhexanol as a novel biomarker for precise diagnosis and prognosis of hepatocellular carcinoma”. Led by Dongyong Lee as the first author, this […]

Our collaborative research on targeted cancer therapeutics using multiplexed CRISPR/Cas9 has been published in Cancer Research. This study was successfully achieved through a joint effort with the research groups of Prof. Seung Woo Cho, Prof. Tae-Eun Park, Prof. Taejoon Kwon, and Prof. Kyungjae Myung. The technology enhances precise therapeutic efficacy by specifically targeting mutated DNA […]

Our collaboration work on long-lived phosphorescence of silica nanoparticles with Profs. Woosung Kwon (Sookmyung Women’s University) and Kyeonghak Kim (Hanyang University) has been published in Chemical Engineering Journal. This work reports a use of defect-engineered silica nanoparticle that presents room-temperature phosphorescence with extended lifetime up to a few milliseconds-scale. Such a long lifetime allows tissue […]

Our collaborative work on biodegradable nanoparticles and controlled ferroptosis has been published in Nano Today. This work reports spatiotemporal tracking of intracellular nanoparticles using multimodal imaging systems including super-resolution microscopy and fluorescence correlation spectroscopy to reveal the ultimate fate of single nanoparticles upon autophagic clearance. Moreover, this study showed controlled ferroptosis upon triggered reduction of […]

A collaborative work with Prof. Hee Ho Park’s lab at Hanyang University for enhanced tissue regeneration using human serum albumin-based protein nanoparticles has been published in Journal of Nanobiotechnology:https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-023-02053-4 In this work, we report significantly improved would healing performance by using human serum albumin-mediated nanoparticle formulation with soluble bFGF. A systematic investigation both in vitro […]

Our collaborative study with Prof. Tae-Eun Park on brain delivery systems for treatment of Alzheimer’s disease has been published in ACS Nano. In this study, we have utilized the microphysiological systems (MPS) mimicking human blood-brain barrier on a chip to discover BBB-penetrating aptamers. The MPS-derived aptamers showed remarkable BBB penetration efficiency, led by clathrin-mediated transcytosis. […]

Our paper entitled “Tailored polyethylene glycol grafting on porous nanoparticles for enhanced targeting and intracellular siRNA delivery” has been published in Nanoscale as an inside front cover. In this study, we proposed a secondary packaging method on mesoporous surface of nanoparticles ensuring high drug loading capacity while preventing protein corona formation for target receptor recognition […]